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The Ultimate Easy John Wayne Casserole with Fluffy Biscuit Topping

A hearty slice of john wayne casserole featuring layers of biscuit base, creamy filling, seasoned ground meat, and melted cheddar cheese topping.

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Make this hearty, cheesy John Wayne Casserole for a satisfying family dinner. This recipe layers seasoned ground beef, creamy vegetables, and a simple biscuit topping for classic American comfort food.

Ingredients

Scale
  • 1 pound ground beef
  • 1 can (10.75 ounces) cream of mushroom soup
  • 1 can (10.5 ounces) cream of chicken soup
  • 1 cup sour cream
  • 1 cup shredded cheddar cheese, divided
  • 1 cup frozen mixed vegetables (peas, carrots, corn)
  • 1/2 cup chopped onion
  • 1 teaspoon chili powder
  • 1/2 teaspoon garlic powder
  • Salt and pepper to taste
  • 1 package (10 ounces) refrigerated biscuit dough

Instructions

  1. Preheat your oven to 375 degrees Fahrenheit. Lightly grease a 9×13 inch baking dish.
  2. Brown the ground beef in a large skillet over medium heat. Drain off any excess grease.
  3. Add the chopped onion to the skillet with the beef and cook until softened, about 3 minutes.
  4. Stir in the cream of mushroom soup, cream of chicken soup, sour cream, 1/2 cup of the cheddar cheese, mixed vegetables, chili powder, garlic powder, salt, and pepper. Mix until everything is combined.
  5. Spread the beef mixture evenly into the prepared baking dish.
  6. Arrange the refrigerated biscuit dough pieces over the top of the beef mixture, leaving small gaps between them.
  7. Bake for 20 minutes, or until the biscuits are puffed and lightly golden brown.
  8. Remove the casserole from the oven and immediately sprinkle the remaining 1/2 cup of cheddar cheese over the hot biscuits.
  9. Return the dish to the oven for 5 more minutes, or until the cheese is fully melted and bubbly.
  10. Let the John Wayne Casserole rest for 5 minutes before cutting and serving.

Notes

  • For a Tex-Mex flavor, substitute the mixed vegetables with one can of drained black beans and one can of drained corn, and add 1/2 teaspoon of cumin to the seasoning.
  • You can prepare the beef mixture ahead of time and store it in the refrigerator for up to two days before assembling and baking.
  • If you prefer a cornbread topping instead of biscuits, use a standard boxed cornbread mix prepared according to package directions and spread over the beef layer before baking.

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